ea0015p192 | Endocrine tumours and neoplasia | SFEBES2008
Leontiou Chrysanthia A
, Gueorguiev Maria
, Hassan Sevda
, van der Spuy Jacqueline
, Lolli Francesca
, Stolbrink Maria
, Christian Helen
, Wray Jennifer
, Bishop-Bailey David
, Berney Dan M
, Frohman Lawrence A
, Chapple Paul J
, Grossman Ashley B
, Korbonits Marta
Mutations in AIP have been identified in a significant proportion of families with pituitary adenomas, most commonly in familial acromegaly. However, no data are available about the pituitary expression of AIP and how lack of AIP is involved in tumorigenesis.We identified 10 kindreds with AIP mutations out of 31 families. We studied RNA and protein expression of AIP in normal as well as familial and sporadic pituitary adenomas. In the normal pituitary st...